MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
SR-717
CAS No. : 2375421-09-1
MCE 国际站:SR-717
产品活性:SR-717 是一种非核苷类 STING 激动剂,在 ISG-THP1 (WT) 和 ISG-THP1 cGAS KO (cGAS KO) 细胞中的 EC50 分别为 2.1 μM 和 2.2 μM。SR-717 是一种稳定的环鸟苷单磷酸腺苷单磷酸 (cGAMP) 类似物。具有抗肿瘤活性。
作用靶点:STING
In Vitro: SR-717 activates STING by inducing the same closed conformation, which thereby provides an avenue to explore this class of systemic STING agonist in diverse contexts, including antitumor immunity.
SR-717 (3.8 μM) induces the expression of PD-L1 in THP1 cells and in primary human peripheral blood mononuclear cells in a STING-dependent manner.
In Vivo: SR-717 (30 mg/kg intraperitoneal once-per-day for 1 week) shows antitumor activities in WT or Stinggt/gt mice.
SR-717 (30 mg/kg intraperitoneally for 7 days) displays antitumor activity; promots the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitates antigen cross-priming.
相关产品:Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Anti-Cancer Compound Library | Small Molecule Immuno-Oncology Compound Library | Immunopotentiator Compound Library | Bioactive Compound Library Max | CCCP | H-151 | Vadimezan | C-176 | 2’3’-c-di-AM(PS)2 (Rp,Rp) (disodium salt) | 2',3'-cGAMP sodium | MSA-2 | Omaveloxolone | SN-011 | diABZI STING agonist-1 trihydrochloride | c-di-AMP disodium | cGAMP disodium | STING-IN-2 | STING agonist-3 | Cyclic-di-GMP disodium | C-178 | STING agonist-1 | STING agonist-12 | PROTAC STING Degrader-1 | IACS-8803 disodium | STING agonist-22 | STING agonist-20 | diABZI-C2-NH2 | SN-001 | STING-IN-3
热门产品线:重组蛋白 | 药物筛选 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。