FITC标记的张力蛋白4抗体
产品名称： FITC标记的张力蛋白4抗体
英文名称： Anti-TNS4/FITC
产品编号： HZ-18162R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-TNS4/FITC Conjugated antibody
FITC标记的张力蛋白4抗体
| 英文名称 | Anti-TNS4/FITC |
| 中文名称 | FITC标记的张力蛋白4抗体 |
| 别 名 | C terminal tensin like; C terminal tensin like protein; C-terminal tensin-like protein; CTEN; FLJ14950; PP14434; TENS4_HUMAN; Tensin 4; Tensin-4; Tns4. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 细胞粘附分子 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 75kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TNS4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Tensin (Tns) family of proteins is involved in the maintenance of cellular structure by anchoring Actin filaments at the focal adhesion via F-Actin binding and capping activities. Tns proteins contain a Src homology 2 (SH2) domain and have the ability to be phosphorylated, suggesting an additional role in signal transduction cascades. These diverse characteristics indicate that Tns proteins may be important links between the cytoskeleton and signal transduction pathways. Tns4 is a 715 amino acid protein that localizes to focal adhesions and contains one SH2 domain and one phosphatase tensin-type domain. Expressed in placenta and prostate, Tns4 binds to Actin filaments and is thought to be involved in cartilage development, cell migration and apoptosis, and may also play a role in linking signal transduction pathways to the cytoskeleton. Tns4 is subject to post-translational phosphorylation and is down-regulated in prostate cancer cells, suggesting a role in tumor suppression Function: May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3. Subcellular Location: Cell junction > focal adhesion. Cytoplasm > cytoskeleton. Tissue Specificity: Prostate and placenta. Down regulated in prostate cancer. Post-translational modifications: Proteolytically cleaved by caspase-3 during apoptosis. Similarity: Contains 1 phosphatase tensin-type domain. Contains 1 SH2 domain. Database links: Entrez Gene: 84951 Human Entrez Gene: 217169 Mouse Omim: 608385 Human SwissProt: Q8IZW8 Human SwissProt: Q8BZ33 Mouse Unigene: 438292 Human Unigene: 262067 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Tensin（TNS）家族的蛋白质参与维持细胞结构锚定肌动蛋白丝通过F-肌动蛋白结合和封盖活动的焦点粘连。TNS蛋白含有Src同源2（SH2）结构域，并具有磷酸化的能力，提示信号转导级联中的附加作用。这些不同的特征表明，TNS蛋白可能是细胞骨架和信号转导通路之间的重要联系。TNS4是一个715个氨基酸的蛋白质，定位为局灶粘连，并含有一个SH2结构域和一个磷酸酶张力蛋白类型域。Tns4表达于胎盘和前列腺，与肌动蛋白丝结合，被认为参与软骨发育、细胞迁移和凋亡，还可能参与连接信号转导途径和细胞骨架。Tns4受翻译后磷酸化的影响，在前列腺癌细胞中下调，提示其在肿瘤抑制中的作用。