分子量:33 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human Mesothelin (aa 296-580), His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:

产品特性:Human Mesothelin (aa 296-580), His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 33 kDa. The predicted N-terminus is Glu 296. The reducing (R) protein migrates as 38-42 kDa in SDS-PAGE  due to glycosylation.

产品背景:Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.