Adenosine Receptor A2a,腺苷A2A受体抗体

产品编号HZ-1456R
英文名称Adenosine Receptor A2a
中文名称腺苷A2A受体抗体
别 名Adenosine Receptor A2a; Adenosine A2A-R; A2AR; A2A adenosine receptor; A2AAR; A2aR; ADENO; Adenosine A2 receptor; Adenosine A2a receptor; Adenosine receptor subtype A2a; Adenosine Receptor A2a; ADORA 2; ADORA2; Adora2a; hA2aR; RDC 8; RDC8; AA2AR_HUMAN.
规格价格0.1ml 0.2ml 
说 明 书0.1ml 0.2ml
研究领域心血管 细胞生物 信号转导 细胞凋亡 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
Adenosine Receptor A2a,腺苷A2A受体抗体交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量45kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human A2AR
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Adenosine Receptor A2a,腺苷A2A受体抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]

Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subunit:
Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct. May interact with DRD4.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Adenosine Receptor A2a,腺苷A2A受体抗体Gene ID:
135

Database links:
Entrez Gene: 135 Human
Entrez Gene: 11540 Mouse
Entrez Gene: 25369 Rat
Omim: 102776 Human
SwissProt: P11617 Dog
SwissProt: P29274 Human
SwissProt: Q60613 Mouse
SwissProt: P30543 Rat
Unigene: 197029 Human
Unigene: 333734 Mouse
Unigene: 11180 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

腺苷A2A受体参与神经递质运输、吞噬、细胞凋亡、炎症应答、细胞防御应答、信号转导。
腺苷是腺嘌呤核苷酸代谢的中间产物。是一种保护正常组织免于炎症损伤的关键的、多余的负调节免疫细胞。由cAMP 生物合成。