PTPN11 polyclonal antibody
产品名称： PTPN11 polyclonal antibody
英文名称： PTPN11 polyclonal antibody
产品编号： PAB13223
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PTPN11.
- Immunogen:
- A synthetic peptide corresponding to N-terminus 14 amino acids of human PTPN11.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection.
Bard-Chapeau EA, Yuan J, Droin N, Long S, Zhang EE, Nguyen TV, Feng GS.Mol Cell Biol. 2006 Jun;26(12):4664-74.
- 2.
- Protein-tyrosine phosphatases and cancer.
Ostman A, Hellberg C, Bohmer FD.Nat Rev Cancer. 2006 Apr;6(4):307-20.
- 3.
- Protein-tyrosine phosphatase SHP2 is positively linked to proteinase-activated receptor 2-mediated mitogenic pathway.
Yu Z, Ahmad S, Schwartz JL, Banville D, Shen SH.J Biol Chem. 1997 Mar 14;272(11):7519-24.
- Entrez GeneID:
- 5781
- Protein Accession#:
- NP_002825
- Gene Name:
- PTPN11
- Gene Alias:
- BPTP3,CFC,MGC14433,NS1,PTP-1D,PTP2C,SH-PTP2,SH-PTP3,SHP2
- Gene Description:
- protein tyrosine phosphatase, non-receptor type 11
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq
- Other Designations:
- protein tyrosine phosphatase-2,protein-tyrosine phosphatase 2C
- Interactome
- Related Disease
- Abnormalities, Multiple
- Addison Disease
- Adenocarcinoma
- Arrhythmias, Cardiac
- Articulation Disorders
- Atrophy
- Cardiovascular Diseases
- Celiac Disease
- Cleft Lip
- Cleft Palate
- Cognition
- Cognition Disorders
- Colitis, Ulcerative
- Craniofacial Abnormalities
- Crohn Disease
- Crohn's disease
- Developmental Disabilities
- Disease Progression
- Down Syndrome