DOCK3; MOCA抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
DOCK3; MOCA抗体

DOCK3; MOCA抗体

商家询价

产品名称: DOCK3; MOCA抗体

英文名称: DOCK3; MOCAAntibody

产品编号: XY20683-1

产品价格: null

产品产地: 中国/美国

品牌商标: XYbscience

更新时间: 2023-08-17T09:55:27

使用范围: WB,ELISA,IHC-P,IHC-F,IF

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 DOCK3; MOCA抗体

Applications
Tested Applications: ELISA, WB
Specificity Reaction: Human, Mouse; Other species are not tested.Please decide the specificity by homology
Positive WB detected in Human brain tissue, SH-SY5Y cells
Recommended dilution WB : 1:500-1:5000
 DOCK3; MOCA抗体Application key: WB=Western Blotting ,IHC=Immunohistochemistry, IF=Immunofluorescence
Images
Prev1NextView more validation data
  • 20683-1-AP;human brain tissuehuman brain tissue were subjected to SDS PAGE followed by western blot with 20683-1-AP(DOCK3; MOCA antibody) at dilution of 1:500
Product Information
Source: Rabbit Purify: Antigen affinity purification
IsoType: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles.
Immunogen Information DOCK3; MOCA抗体
Immunogen: Peptide Full Name: Dedicator of cytokinesis 3
Caculated Molecular
Weight:
233 kDa Observed Molecular 
Weight:
233 kDa
GenbankNo NM_004947 GeneID: 1795
Symbol DOCK3 Synonyms Dedicator of cytokinesis 3, DOCK3, KIAA0299, MOCA, Modifier of cell adhesion, PBP, Presenilin binding protein
Background

Dedicator of cytokinesis3 (DOCK3) , also named as MOCA and PBP , is a ~180 kDa protein involved in signaling trasduction. It is a potential guanine nucleotide exchange factor (GEF) which activate some small GTPases by exchanging bound GDP for free GTP. DOCK3 is associated in Alzheimer disease tangles and regulates the accumulation of amyloid precursor protein and beta-amyloid. Overexpression of Dock3 in neural cells promotes axonal outgrowth downstream of brain-derived neurotrophic factor (BDNF) signaling. DOCK3 binds to and inactivates glycogen synthase kinase-3β (GSK-3β) at the plasma membrane, thereby promoteing axon branching and microtubule assembly. By stimulating actin polymerization and microtubule assembly, DOCK3 plays important roles downstream of BDNF signaling in the CNS. DOCK3; MOCA抗体

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