分子量:38.3 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Cynomolgus CD3 epsilon, His Tag & Fc Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:

产品特性:Cynomolgus CD3 epsilon, His Tag & Fc Tag , and has a calculated MW of 38.3 kDa. The predicted N-terminus is Gln 22. The reducing (R) protein migrates as 40-50 kDa in SDS-PAGE  due to glycosylation.

产品背景:CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.