FITC标记的天门冬氨酸β羟化酶抗体
产品名称： FITC标记的天门冬氨酸β羟化酶抗体
英文名称： Anti-Aspartate beta hydroxylase/FITC
产品编号： HZ-12137R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-Aspartate beta hydroxylase/FITC Conjugated antibody
FITC标记的天门冬氨酸β羟化酶抗体
| 英文名称 | Anti-Aspartate beta hydroxylase/FITC |
| 中文名称 | FITC标记的天门冬氨酸β羟化酶抗体 |
| 别 名 | ASP beta hydroxylase; Aspartyl/asparaginyl beta hydroxylase; ASPH; BAH; CASQ2BP1; HAAH; JCTN; junctin; Peptide aspartate beta dioxygenase; ASPH_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 86kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ASPH/Aspartate beta hydroxylase |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Aspartyl/asparaginyl beta-hydroxylase (ASPH) is a widely-expressed type II membrane protein involved in calcium homeostasis. Located in the endoplasmic reticulum, ASPH specifically hydroxylates an Asp or Asn residue in the epidermal growth factor-like (EGF) domains of several proteins, using iron as a cofactor. The ASPH gene encodes 3 proteins, ASPH, Junctin, and Junctate (or Humbug), that differ significantly in their C-terminal domains. These ASPH gene products are expressed as five transcript variants that differ by their roles in calcium storage and release, hydroxylation capabilities, and tissue specificity. While all ASPH variants are expressed in skeletal muscle, only some are detected in heart, brain, pancreas, placenta, lung, liver, and kidney tissues. In the lumen of the endoplasmic reticulum, ASPH can be processed into two different forms. Function: ASPH is thought to play an important role in calcium homeostasis. Alternative splicing of this gene results in five transcript variants which vary in protein translation, the coding of catalytic domains, and tissue expression. Variation among these transcripts impacts their functions which involve roles in the calcium storage and release process in the endoplasmic and sarcoplasmic reticulum as well as hydroxylation of aspartic acid and asparagine in epidermal growth factor like domains of various proteins. Subunit: Monomer (By similarity). Isoform 8 interacts with ORAI1 and STIM1. Subcellular Location: Isoform 1: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Isoform 8: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Tissue Specificity: Isoform 1 is detected in all tissues tested. Isoform 8 is mainly expressed in pancreas, heart, brain, kidney and liver. Isoform 8 is expressed in kidney (at protein level). Similarity: Endoplasmic reticulum; endoplasmic reticulum membrane; Single-pass type II membrane protein. Database links: Entrez Gene: 444 Human Omim: 600582 Human SwissProt: Q12797 Human Unigene: 332422 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
天冬氨酸/天冬酰胺基β-羟化酶（ASPH）是一种广泛表达的II型膜蛋白，参与钙稳态。ASPH位于内质网中，利用铁作为辅助因子，特异性地将Asp或Asn残基羟化在几种蛋白质的表皮生长因子样结构域（EGF）中。ASPH基因编码3种蛋白，ASPH、Junctin和连接蛋白（或Hubbug），它们的C-末端结构域有显著差异。这些ASPH基因产物被表达为五个转录体变体，它们在钙的储存和释放、羟基化能力和组织特异性方面的作用不同。虽然所有的ASPH变异体都在骨骼肌中表达，但只有一些在心脏、大脑、胰腺、胎盘、肺、肝脏和肾脏组织中检测到。在内质网的内腔中，ASPH可以被加工成两种不同的形式。