phospho-beta Adducin,磷酸化内收蛋白抗体

产品编号HZ-12960R
英文名称phospho-beta Adducin (Ser713)
中文名称磷酸化内收蛋白抗体
别 名beta Adducin (phospho S713); p-beta Adducin (phospho S713); phospho-alpha Adducin(Ser726); phospho-gamma Adducin(Ser693); ADD1; ADD2; ADD3; ADDA; ADDB; ADDL; Adducin 1 (alpha); Adducin 1; Adducin 2 (beta); Adducin 2; Adducin 3 (gamma); Adducin 3; Adducin like; Alpha adducin; Beta adducin.
说 明 书0.1ml
产品类型磷酸化抗体
研究领域细胞生物 信号转导 细胞类型标志物 细胞骨架
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Zebrafish,
phospho-beta Adducin,磷酸化内收蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量80kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human beta Adducin around the phosphorylation site of Ser713
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
phospho-beta Adducin,磷酸化内收蛋白抗体PubMedPubMed
产品介绍background:
Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha and beta adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha and gamma adducins are ubiquitously expressed. In contrast, beta adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca2+/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.

Function:
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.

Subunit:
Heterodimer of an alpha and a beta subunit.

Subcellular Location:
Membrane-cytoskeleton-associated protein.

Tissue Specificity:
Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line.

Post-translational modifications:
The N-terminus is blocked.

Similarity:
Belongs to the aldolase class II family. Adducinbn subfamily.

Gene ID:
119

Database links:
Entrez Gene: 119 Human
Entrez Gene: 11519 Mouse
Entrez Gene: 24171 Rat
Omim: 102681 Human
SwissProt: P35612 Human
SwissProt: Q9QYB8 Mouse
SwissProt: Q05764 Rat
Unigene: 188528 Human
Unigene: 11353 Rat

phospho-beta Adducin,磷酸化内收蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.