分子量:13 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human VEGF-D, His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:The bioactivity was measured by its ability to stimulate the cell proliferation of human microvascular endothelial cells (HMVECs). The ED50 for this effect is typically 50200 ng/mL.

产品特性:Human VEGF-D, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 13 kDa. The predicted N-terminus is Phe 93. The reducing (R) protein migrates as 18-20 kDa in SDS-PAGE  due to different glycosylation.

产品背景:Vascular endothelial growth factor D (VEGF-D) is also known as C-fos induced growth factor (FIGF), which belongs to the PDGF / VEGF growth factor family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. This secreted protein VEGF-D / FIGF undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3. The structure and function of this protein is similar to those of VEGFC. FIGF / VEGF-D is highly expressed in lung, heart, small intestine and fetal lung. FIGF / VEGF-D may function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR / FLK1) and VEGFR-3 (FLT4) receptors.