Apelin,脂肪炎症因子Apelin抗体

产品编号HZ-2425R
英文名称Apelin
中文名称脂肪炎症因子Apelin抗体
别 名AGTRL1 ligand; APEL; APEL_HUMAN; Apelin-13; Apelin13; Apelin 13; APJ endogenous ligand; Apln; XNPEP2.
规格价格0.1ml 0.2ml 
说 明 书0.1ml 0.2ml
研究领域心血管
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
Apelin,脂肪炎症因子Apelin抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量10kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Apelin
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Apelin,脂肪炎症因子Apelin抗体PubMedPubMed
产品介绍background:
Apelin is a neuropeptide expressed in the supraoptic and paraventricular nuclei and is an endogenous ligand for APJ, a G protein-coupled orphan receptor which is an alternative coreceptor with CD4 for HIV-1. Apelin and APJ are ubiquitously expressed in peripheral tissues, with highest levels reported for heart and lungs, as well several regions within the central nervous system. The actions of apelin remain largely unknown: Apelin inhibits HIV-1 entry in cells coexpressing CD4 and APJ; the oral intake of Apelin in colostrum and breast milk could have a role in the modulation of the immune responses in neonates; more recent studies have also indicated a role for Apelin in the central control of body fluid homeostasis, by influencing AVP release and drinking behavior. In the cardiovascular system several actions of Apelin have been described, including endothelium-dependent vasodilatation, vasoconstriction through direct action on smooth muscle and positive inotropism.

Function:
Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior.

Apelin,脂肪炎症因子Apelin抗体Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain. Secreted by the mammary gland into the colostrum and the milk.

Post-translational modifications:
Several active peptides may be produced by proteolytic processing of the peptide precursor.

Similarity:
Belongs to the apelin family.

Gene ID:
8862

Database links:
Entrez Gene: 8862 Human
Entrez Gene: 30878 Mouse
Entrez Gene: 58812 Rat
Omim: 300297 Human
SwissProt: Q9ULZ1 Human
SwissProt: Q9R0R4 Mouse
SwissProt: Q9R0R3 Rat
Unigene: 303084 Human
Unigene: 29262 Mouse
Unigene: 22847 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

脂肪炎症因子apelin是血管紧张素Ⅱ-1型受体相关蛋白的天然内源性配体，是新发现的小分子活性多肽，为孤儿G蛋白偶联受体一血管紧张素受体AT-1相关蛋白(APJ)的天然配体具有调节心血管系统稳态、扩张血管、降低血压、调节免疫等多种生物学作用。