Mouse B7-H5 / Gi24 / VISTA Protein-蛋白质/抗原/多肽-试剂-生物在线
北京百普赛斯生物科技股份有限公司
Mouse B7-H5 / Gi24 / VISTA Protein

Mouse B7-H5 / Gi24 / VISTA Protein

商家询价

产品名称: Mouse B7-H5 / Gi24 / VISTA Protein

英文名称: Mouse B7-H5 / Gi24 / VISTA Protein

产品编号: B75-M52H7

产品价格: 0

产品产地: USA

品牌商标: ACROBiosystems

更新时间: null

使用范围: null

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分子量:24 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human TIMP1, His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:Measured by its ability to inhibit human MMP2 cleavage of a fluorogenic peptide substrate Mca-PLGL-Dpa-AR-NH2. The IC50 value is approximately 2.5 nM.

产品特性:Human TIMP1, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 24 kDa. The predicted N-terminus is Cys 24. The reducing (R) protein migrates as 28-32 kDa in SDS-PAGE  due to glycosylation.

产品背景:TIMP metallopeptidase inhibitor 1 is also known as TIMP1, a tissue inhibitor of metalloproteinases, is a glycoprotein that is expressed from the several tissues of organisms. This protein a member of the TIMP family.There are four members of the family, TIMP1,TIMP2,TIMP3 and TIMP4. TIMP1 is a glycoprotein with a molecular mass of 28 kDa produced by a wide range of cell types. The glycoprotein is a natural inhibitor of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. 
SDS-PAGE