CEP63,中心体蛋白63抗体

产品编号HZ-13859R
英文名称CEP63
中文名称中心体蛋白63抗体
别 名Centrosomal protein 63kDa; CEP63_HUMAN; Centrosomal protein of 63 kDa; centrosome protein CEP63.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
CEP63,中心体蛋白63抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量81kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CEP63
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CEP63,中心体蛋白63抗体PubMedPubMed
产品介绍background:
This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Several alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Function:
Required for normal spindle assembly. Maintains centrosome numbers through centrosomal recruitment of CEP152. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity).

Subunit:
Interacts with CEP152 and CDK1; these interactions recruit both ligands to centrosomes. May also interact with CDK2.

Subcellular Location:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with CEP152 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles.

DISEASE:
Seckel syndrome 6 (SCKL6) [MIM:614728]: A rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the CEP63 family.

Gene ID:
80254

Database links:

Entrez Gene: 80254 Human
Omim: 614724 Human
SwissProt: Q96MT8 Human
Unigene: 443301 Human

CEP63,中心体蛋白63抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.