分子量:55.1 kDa

纯度:>92% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human DLL4, His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:Measured by its ability to bind human Notch1 in a functional ELISA.

产品特性:Human DLL4, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 55.1 kDa. The predicted N-terminus is Ser 27. The reducing (R) protein migrates as 65 kDa in SDS-PAGE  due to glycosylation.

产品背景:Delta-like protein 4 (DLL4) is also known as Drosophila Delta homolog 4 (Delta4), which contains one DSL domain and eight EGF-like domains. DLL4 is expressed in vascular endothelium. DLL4 is involved in the Notch signaling pathway as Notch ligand, which can activates NOTCH1 and NOTCH4. DLL4 is involved in angiogenesis and negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. DLL4 can bind to Notch-1 and Notch-4.