SNCA polyclonal antibody
产品名称： SNCA polyclonal antibody
英文名称： SNCA polyclonal antibody
产品编号： PAB18226
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of SNCA.
- Immunogen:
- A synthetic peptide corresponding to residues surrounding S129 of human SNCA.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody is specific to SNCA.
- Form:
- Liquid
- Purification:
- Affinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Mol Cell Biol. 2003 Nov;23(22):8233-45.
Ninkina N, Papachroni K, Robertson DC, Schmidt O, Delaney L, O'Neill F, Court F, Rosenthal A, Fleetwood-Walker SM, Davies AM, Buchman VL.Mol Cell Biol. 2003 Nov;23(22):8233-45.
- 2.
- Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2884-9. Epub 2003 Feb 24.
Kirik D, Annett LE, Burger C, Muzyczka N, Mandel RJ, Bjorklund A.Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2884-9. Epub 2003 Feb 24.
- 3.
- J Biol Chem. 2002 Oct 11;277(41):38884-94. Epub 2002 Jul 26.
Lotharius J, Barg S, Wiekop P, Lundberg C, Raymon HK, Brundin P.J Biol Chem. 2002 Oct 11;277(41):38884-94. Epub 2002 Jul 26.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from HUVEC cells, using SNCA polyclonal antibody (Cat # PAB18226).
Peptide "+" means "peptide blocking".
- Entrez GeneID:
- 6622
- Protein Accession#:
- P37840
- Gene Name:
- SNCA
- Gene Alias:
- MGC110988,NACP,PARK1,PARK4,PD1
- Gene Description:
- synuclein, alpha (non A4 component of amyloid precursor)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000161559,OTTHUMP00000161561,alpha synuclein,alpha-synuclein,alpha-synuclein, isoform NACP140,non A-beta component of AD amyloid,non A4 component of amyloid
- Interactome
- Gene Pathway
- Related Disease
- Alcoholism
- Alzheimer Disease
- Alzheimer disease
- Amphetamine-Related Disorders
- Association Learning
- Attention
- Cardiovascular Diseases
- Chromosome Breakage
- Cognition Disorders
- Color Perception
- Cystic Fibrosis
- Cystic fibrosis
- Dementia
- Diabetes Complications
- Disease Progression
- Disease Susceptibility
- Essential Tremor
- Essential tremor
- Genetic Predisposition to Disease