FITC标记的滋养层细胞糖蛋白5T4抗体
产品名称： FITC标记的滋养层细胞糖蛋白5T4抗体
英文名称： Anti-5T4/FITC
产品编号： HZ-12348R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-5T4/FITC Conjugated antibody
FITC标记的滋养层细胞糖蛋白5T4抗体
| 英文名称 | Anti-5T4/FITC |
| 中文名称 | FITC标记的滋养层细胞糖蛋白5T4抗体 |
| 别 名 | 5T4; 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrophoblast glycoprotein; 5T4AG; M6P1; TPBG; TPBG_HUMAN; Trophoblast glycoprotein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 发育生物学 干细胞 转录调节因子 糖蛋白 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 43kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TPBG/5T4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: TPBG is a 420 amino acid single-pass type I membrane protein expressed by all types of trophoblasts as early as 9 weeks of development. TPBG contains an N-terminal putative signal sequence, a 310-residue extracellular region, a membrane anchorage domain and a 44-amino acid cytoplasmic tail with a potential phosphorylation site. The extracellular region has seven potential N-glycosylation sites and seven leucine-rich repeats, which are located in two regions separated by a hydrophilic stretch. Suggested to be involved in cell adhesion, TPBG may also be associated with tumor growth and progression. Subcellular Location: Membrane. Tissue Specificity: Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma. Similarity: Contains 6 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. Database links: Entrez Gene: 7162 Human Entrez Gene: 21983 Mouse Entrez Gene: 83684 Rat Omim: 190920 Human SwissProt: Q13641 Human SwissProt: Q9Z0L0 Mouse SwissProt: Q5PQV5 Rat Unigene: 82128 Human Unigene: 20864 Mouse Unigene: 484180 Mouse Unigene: 43122 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
TPBG是一种420个氨基酸的单程I型膜蛋白，最早于9周的发育过程中由所有滋养层细胞表达。TPBG包含一个N-末端假定的信号序列，一个310个残基的胞外区，一个膜锚定域和44个氨基酸胞质尾，具有潜在的磷酸化位点。胞外区具有七个潜在的N-糖基化位点和七个富含亮氨酸的重复序列，它们位于亲水性伸展区分开的两个区域中。建议参与细胞粘附，TPBG也可能与肿瘤的生长和进展有关。