FITC标记的脑蛋白丝氨酸/苏氨酸激酶29抗体
产品名称： FITC标记的脑蛋白丝氨酸/苏氨酸激酶29抗体
英文名称： Anti-BRSK2/FITC
产品编号： HZ-11810R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-BRSK2/FITC Conjugated antibody
FITC标记的脑蛋白丝氨酸/苏氨酸激酶29抗体
| 产品编号 | bs-11810R-FITC |
| 英文名称 | Anti-BRSK2/FITC |
| 中文名称 | FITC标记的脑蛋白丝氨酸/苏氨酸激酶29抗体 |
| 别 名 | BR serine/threonine kinase 2; BR serine/threonine-protein kinase 2; Brain selective kinase 2; Brain specific serine/threonine protein kinase 2; Brsk2; BRSK2_HUMAN; C11orf7; PEN11B; Protein kinase SAD1B; SAD1; Serine/threonine kinase 29; Serine/threonine protein kinase BRSK2; Serine/threonine-protein kinase 29; Serine/threonine-protein kinase SAD-A; STK29; SADA. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 神经生物学 激酶和磷酸酶 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 82kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human STK29 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. BRSK2 (BR serine/threonine kinase 2), also known as SAD1, STK29 or PEN11B, is a 736 amino acid protein that contains one protein kinase domain and is preferentially expressed in brain and testis. One of several members of the Ser/Thr protein kinase family, BRSK2 uses magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins and is thought to be involved in microtubule assembly, neuronal polarization and synaptic development. Additionally, BRSK2 may function as an autoantigen involved in small-cell lung cancer-associated limbic encephalitis. Five isoforms of BRSK2 exist due to alternative splicing events. Function: Required for the polarization of forebrain neurons which endows axons and dendrites with distinct properties, possibly by locally regulating phosphorylation of microtubule-associated proteins. Subcellular Location: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily. Contains 1 protein kinase domain. Post-translational modifications: Phosphorylated at Thr-174 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not phosphorylated at Thr-174 by CaMKK2. In contrast, it is phosphorylated and activated by CaMKK1. May be inactivated via dephosphorylation of Thr-174 by PP2C. May be phosphorylated at Thr-260 by PKA. However, phosphorylation at Thr-260 by PKA was not comfirmed later (PubMed:18339622). Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Contains 1 protein kinase domain. Contains 1 UBA domain. Database links: Entrez Gene: 9024 Human Entrez Gene: 75770 Mouse Omim: 609236 Human SwissProt: Q8IWQ3 Human SwissProt: Q69Z98 Mouse Unigene: 170819 Human Unigene: 274868 Mouse Unigene: 482784 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
蛋白在丝氨酸和苏氨酸残基上的磷酸化和去磷酸化是调节真核细胞中广泛的细胞功能的重要手段，包括细胞分裂、稳态和凋亡。一组紧密参与这一过程的蛋白质是丝氨酸/苏氨酸（SE/THR）蛋白激酶。BRSK2（BR丝氨酸/苏氨酸激酶2），也称为SAD1，STK29或PN11B，是包含一个蛋白激酶结构域并在大脑和睾丸中优先表达的736氨基酸蛋白。SR/THR蛋白激酶家族的几个成员之一，BRSK2使用镁作为辅因子催化靶蛋白的ATP依赖性磷酸化，并被认为参与微管组装、神经元极化和突触发育。此外，BRSK2可以作为参与小细胞肺癌相关边缘脑炎的自身抗原。BRSK2的五种异构体由于选择性剪接事件而存在。