DLEC1,肺癌和食道癌缺失基因1抗体

产品编号HZ-14341R
英文名称DLEC1
中文名称肺癌和食道癌缺失基因1抗体
别 名Deleted in lung and esophageal cancer 1; Deleted in lung and esophageal cancer 1 transcript varient 2; Deleted in lung and esophageal cancer protein 1; Deleted in lung cancer protein 1; DLC 1; Dlc-1; DLC1; Dlec1; DLEC1_HUMAN; F56.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,
DLEC1,肺癌和食道癌缺失基因1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量196kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DLEC1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DLEC1,肺癌和食道癌缺失基因1抗体PubMedPubMed
产品介绍background:
This gene contains 37 exons, spans approximately 59-kb, and is located in the 3p22-p21.3 chromosomal segment that is commonly deleted in various carcinomas. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins. Aberrant transcription of this gene may be involved in carcinogenesis of the lung, esophagus, and kidney. [provided by RefSeq, Jul 2008]

Function:
May act as a tumor suppressor by inhibiting cell proliferation.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in all tissues examined. Expression is highest in prostate and testis.

DISEASE:
Note=DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of different cancers, including esophageal, renal and lung cancers.

Gene ID:
9940

DLEC1,肺癌和食道癌缺失基因1抗体Database links:
Entrez Gene: 9940 Human
Omim: 604050 Human
SwissProt: Q9Y238 Human
Unigene: 714499 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.