DKK4,抑制因子DKK4抗体

产品编号HZ-14338R
英文名称DKK4
中文名称抑制因子DKK4抗体
别 名Dickkopf 4; Dickkopf gene 4; Dickkopf homolog 4 (Xenopus laevis); Dickkopf homolog 4; Dickkopf related protein 4; Dickkopf-4; Dickkopf-related protein 4 short form; Dickkopf4; DKK 4; Dkk-4; DKK4; DKK4_HUMAN; hDkk 4; hDkk-4; hDkk4; MGC129562; MGC129563.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 神经生物学 信号转导 干细胞 细胞分化
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
DKK4,抑制因子DKK4抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量23kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DKK4
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DKK4,抑制因子DKK4抗体PubMedPubMed
产品介绍background:
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]

Function:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in cerebellum, T-cells, esophagus and lung.

Post-translational modifications:
Appears to be not glycosylated.
Can be proteolytically processed by a furin-like protease.

Similarity:
Belongs to the dickkopf family.

Gene ID:
27121

DKK4,抑制因子DKK4抗体Database links:
Entrez Gene: 27121 Human
Entrez Gene: 234130 Mouse
Entrez Gene: 502097 Rat
GenBank: NP_055235.1 Human
Omim: 605417 Human
SwissProt: Q9UBT3 Human
SwissProt: Q8VEJ3 Mouse
Unigene: 159311 Human
Unigene: 157322 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.