MAPK8 (phospho Y185) Peptide
产品名称： MAPK8 (phospho Y185) Peptide
英文名称： MAPK8 (phospho Y185) Peptide
产品编号： P1562
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of MAPK8 .
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y185 of human MAPK8 .
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- A JNK-dependent pathway is required for TNFalpha-induced apoptosis.
Deng Y, Ren X, Yang L, Lin Y, Wu X.Cell. 2003 Oct 3;115(1):61-70.
- 2.
- Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase.
Ghosh J.Biochem Biophys Res Commun. 2003 Jul 25;307(2):342-9.
- 3.
- Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation.
Luo W, Ng WW, Jin LH, Ye Z, Han J, Lin SC.J Biol Chem. 2003 Sep 26;278(39):37451-8. Epub 2003 Jul 23.
- Entrez GeneID:
- 5599
- Protein Accession#:
- P45983
- Gene Name:
- MAPK8
- Gene Alias:
- JNK,JNK1,JNK1A2,JNK21B1/2,PRKM8,SAPK1
- Gene Description:
- mitogen-activated protein kinase 8
- Omim ID:
- 601158
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
- Other Designations:
- JNK1 alpha protein kinase,JNK1 beta protein kinase,JUN N-terminal kinase,OTTHUMP00000019552,OTTHUMP00000019555,OTTHUMP00000019556,OTTHUMP00000019558,c-Jun N-terminal kinase 1,mitogen-activated protein kinase 8 isoform JNK1 alpha1,mitogen-activated protein
- Interactome
- Gene Pathway
- Adipocytokine signaling pathway
- Colorectal cancer
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Focal adhesion
- GnRH signaling pathway
- Insulin signaling pathway
- MAPK signaling pathway
- Neurotrophin signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Toll-like receptor signaling pathway
- Type II diabetes mellitus
- Wnt signaling pathway