新冠病毒S蛋白突变|英国南非巴西突变|Biotinylated SARS-CoV-2 S protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T
产品名称： 新冠病毒S蛋白突变|英国南非巴西突变|Biotinylated SARS-CoV-2 S protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T
英文名称： Biotinylated SARS-CoV-2 S protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H) trimer, His,Avitag (MALS verified)
产品编号： SPN-C82E5
产品价格： 0
产品产地： USA
品牌商标： ACROBiosystems
更新时间： null
使用范围： null
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Biotinylated SARS-CoV-2 S protein trimer, His,Avitag (SPN-C82E5) is expressed from human 293 cells (HEK293). It contains AA Val 16 - Pro 1213 (Accession # QHD43416.1). The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P/ A892P/ A899P/ A942P/ K986P/ V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively. HV69-70del/ Y144del/ N501Y/ A570D/ D614G/ P681H/ T716I/ S982A/ D1118H/ mutations were identified on the spike protein in the SARS-CoV-2 variant (known as B.1.1.7, 20B/501Y.V1 or VOC 202012/01) which emerged in the United Kingdom.
Molecular Characterization
Molecular Weight:
139.4 kDaPurity:
>95% as determined by SDS-PAGE.Endotoxin:
Less than 1.0 EU per μg by the LAL method.Bioactivity:
