EPO,红细胞生成素抗体

产品编号HZ-2343R
英文名称EPO
中文名称红细胞生成素抗体
别 名Erythropoietin precursor; EP; EPO alpha; EPO; Epoetin; Erythropoetin; Erythropoietin; MGC138142; EPO_HUMAN.
说 明 书0.1ml 0.2ml
研究领域心血管 细胞生物 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
EPO,红细胞生成素抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量28kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Erythropoietin
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
EPO,红细胞生成素抗体PubMedPubMed
产品介绍background:
Human erythropoietin is member of the EPO/TPO family and encodes a secreted, glycosylated cytokine hormone composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. It is produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

Function:
Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.

Subcellular Location:
Secreted.

Tissue Specificity:
Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

DISEASE:
Microvascular complications of diabetes 2 (MVCD2) [MIM:612623]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Similarity:
Belongs to the EPO/TPO family.

Gene ID:
2056

EPO,红细胞生成素抗体Database links:
Entrez Gene: 404002 Dog
Entrez Gene: 2056 Human
Entrez Gene: 13856 Mouse
Entrez Gene: 24335 Rat
Omim: 133170 Human
SwissProt: P33707 Dog
SwissProt: P01588 Human
SwissProt: P07321 Mouse
SwissProt: P29676 Rat
Unigene: 2303 Human
Unigene: 349116 Mouse
Unigene: 11365 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.