FITC标记的葡萄糖调节蛋白78/热休克蛋白70蛋白5抗体
产品名称： FITC标记的葡萄糖调节蛋白78/热休克蛋白70蛋白5抗体
英文名称： Anti-GRP78/FITC
产品编号： HZ-1219R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-GRP78/FITC Conjugated antibody
FITC标记的葡萄糖调节蛋白78/热休克蛋白70蛋白5抗体
| 英文名称 | Anti-GRP78/FITC |
| 中文名称 | FITC标记的葡萄糖调节蛋白78/热休克蛋白70蛋白5抗体 |
| 别 名 | BIP; HSPA5; GRP-78; glucose regulated protein 78; 78 kDa glucose regulated protein; BIP; Endoplasmic reticulum lumenal Ca2+ binding protein grp78; FLJ26106; Glucose Regulated Protein 78kDa; GRP 78; GRP78; Heat Shock 70kDa Protein 5; HSPA 5; HSPA-5; HSPA5; Immunoglobulin Heavy Chain Binding Protein; MIF2; GRP78_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 78kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GRP78 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor. Function: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Subcellular Location: Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. DISEASE: Note=Autoantigen in rheumatoid arthritis. Similarity: Belongs to the heat shock protein 70 family. Database links: Entrez Gene: 3309 Human Entrez Gene: 14828 Mouse Entrez Gene: 25617 Rat Omim: 138120 Human SwissProt: P11021 Human SwissProt: P20029 Mouse SwissProt: P06761 Rat Unigene: 605502 Human Unigene: 743241 Human Unigene: 330160 Mouse Unigene: 470180 Mouse Unigene: 11088 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 葡萄糖调节蛋白78是热休克蛋白70家族的成员之一，又称：热休克蛋白70蛋白5,作为一种分子伴侣在蛋白质的折叠和转运过程及内质网应激反应中发挥重要作用.它在多种肿瘤组织中呈高表达 |
78 kDa葡萄糖调节蛋白/BIP（GRP78）属于70 kDa热休克蛋白（HSP 70）家族。GRP78是内质网(ER)的驻留蛋白，可短暂地与各种新合成的分泌和膜蛋白或永久地与不正确折叠的突变或缺陷蛋白结合，从而阻止它们从ER腔出口。GRP78是一种高度保守的蛋白质，是细胞生存力所必需的。高度保守的序列Lys-Asp-Glu-Leu(KDEL)存在于GRP78和包括葡萄糖调节蛋白94(GRP 94)和蛋白二硫异构酶(PDI)在内的其他ER蛋白的C端上。羧基末端KDEL的存在似乎对保留是必要的，并且似乎足以减少ER的蛋白质的分泌。据报道，这种保留是由KDEL受体介导的。