FITC标记的干扰素诱导蛋白P78抗体
产品名称： FITC标记的干扰素诱导蛋白P78抗体
英文名称： Anti-MX1/FITC
产品编号： HZ-10984R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MX1/FITC Conjugated antibody
FITC标记的干扰素诱导蛋白P78抗体
| 英文名称 | Anti-MX1/FITC |
| 中文名称 | FITC标记的干扰素诱导蛋白P78抗体 |
| 别 名 | Human interferon regulated resistance GTP binding protein MXA; IFI 78; IFI 78K; IFI-78K; IFI78; IFI78K; Interferon induced GTP binding protein Mx1; Interferon induced protein p78; Interferon inducible protein p78; Interferon regulated resistance GTP binding protein; Interferon regulated resistance GTP binding protein MxA; Interferon-induced GTP-binding protein Mx1; Interferon-induced protein p78; Interferon-regulated resistance GTP-binding protein MxA; MX 1; MX; MX1; MX1_HUMAN; MxA; Myxoma resistance protein 1; Myxovirus (influenza virus) resistance 1 interferon inducible; Myxovirus (influenza virus) resistance 1 interferon inducible protein p78; Myxovirus (influenza) resistance 1 homolog of murine; Myxovirus resistance protein 1; N-terminally processed. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Dog, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 73/79kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MX1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Dynamin family of microtubule-associated proteins function as GTPases that are involved in microtubule bundling and endocytosis. In mice, Mx2 (myxovirus resistance protein 2) and Mx1 (myxovirus resistance protein 1) are members of the Dynamin family that are involved in the immune response to viral infections. Localized to the cytoplasm, Mx2 contains one GED domain and is expressed in response to viral infection or treatment by IFN-alpha/IFN-beta. Once expression is induced, Mx2 accumulates in the cytoplasm and inhibits the replication of vesicular stomatitis virus (VSV), thereby conferring resistance to VSV infection. Unlike Mx2, Mx1 is localized to the nucleus where, upon induction by IFN-alpha/IFN-beta, it provides selective resistance to infection by the highly lethal H5N1 influenza virus. In humans, MxA and MxB function in a similar manner to Mx1 and Mx2, conferring resistance to specific target viruses. Mx3 is a rat-specific member of the myxovirus resistance protein family. Function: May regulate the calcium channel activity of TRPCs. Shows activity against influenza virus and VSV, a rhabdovirus. Subunit: Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7. Subcellular Location: Cytoplasm. Similarity: Belongs to the dynamin family. Contains 1 GED domain. Database links: Entrez Gene: 403745 Dog Entrez Gene: 4599 Human Omim: 147150 Human SwissProt: Q9N0Y3 Dog SwissProt: P20591 Human Unigene: 517307 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
微管相关蛋白Dynamin家族作为GTPase发挥作用，参与微管束缚和内吞作用。在小鼠中，Mx2（粘病毒抗性蛋白2）和Mx1（粘病毒抗性蛋白1）是Dynamin家族的成员，参与对病毒感染的免疫应答。Mx2定位于细胞质，包含一个GED结构域，在病毒感染或经IFN-α/IFN-β治疗时表达。一旦诱导表达，Mx2在细胞质中积累并抑制水泡性口炎病毒（VSV）的复制，从而赋予VSV感染的抵抗力。与Mx2不同，Mx1定位于细胞核，在IFN-α/IFN-β的诱导下，Mx1对高致死性H5N1流感病毒的感染提供选择性抗性。在人类中，MXA和MXB以类似于MX1和MX2的方式发挥作用，赋予对特定靶病毒的抗性。MX3是粘液病毒抗性蛋白家族的大鼠特异性成员。