PTEN (phospho S380/T382/T383) polyclonal antibody
产品名称： PTEN (phospho S380/T382/T383) polyclonal antibody
英文名称： PTEN (phospho S380/T382/T383) polyclonal antibody
产品编号： PAB25276
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of PTEN.
- Immunogen:
- Synthetic phosphopeptide corresponding to residues surrounding S380/T382 of human PTEN.
- Sequence:
- R-Y-Sp-D-Tp-Tp-D-S
- Host:
- Rabbit
- Theoretical MW (kDa):
- 54
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Purification:
- Affinity chromatography
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1:1000)
Immunofluorescence (1:100-1:200)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from HT-29 cells untreated or treated with calyculin A using PTEN (phospho S380/T382/T383) polyclonal antibody (Cat # PAB25276).
- Entrez GeneID:
- 5728
- Protein Accession#:
- P60484
- Gene Name:
- PTEN
- Gene Alias:
- 10q23del,BZS,MGC11227,MHAM,MMAC1,PTEN1,TEP1
- Gene Description:
- phosphatase and tensin homolog
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq
- Other Designations:
- MMAC1 phosphatase and tensin homolog deleted on chromosome 10,OTTHUMP00000020032,mutated in multiple advanced cancers 1
- Related Disease
- Abnormalities, Multiple
- Adenocarcinoma
- Adenocarcinoma, Papillary
- Alzheimer Disease
- Alzheimer disease
- Astrocytoma
- Autistic Disorder
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma, Endometrioid
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Cleft Lip
- Cleft Palate
- Colon cancer
- Colonic Neoplasms
- Colorectal Neoplasms
- Craniofacial Abnormalities