CD70 monoclonal antibody, clone BU69
产品名称： CD70 monoclonal antibody, clone BU69
英文名称： CD70 monoclonal antibody, clone BU69
产品编号： MAB6921
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native CD70.
- Immunogen:
- Native purified CD70 from human WM-1 (Waldenstrom's macroglobulinemia) cell line.
- Host:
- Mouse
- Theoretical MW (kDa):
- 30
- Reactivity:
- Human
- Specificity:
- This antibody recognizes CD70.
- Form:
- Liquid
- Isotype:
- IgG1
- Storage Buffer:
- In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
- Storage Instruction:
- Store at 4°C.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- Soluble CD27 induces IgG production through activation of antigen-primed B cells.
Dang LV, Nilsson A, Ingelman-Sundberg H, Cagigi A, Gelinck LB, Titanji K, De Milito A, Grutzmeier S, Hedlund J, Kroon FP, Chiodi F.J Intern Med. 2012 Mar;271(3):282-293. doi: 10.1111/j.1365-2796.2011.02444.x. Epub 2011 Sep 14.
- 2.
- Lipopolysaccharide stimulation converts vigorously washed dendritic cells (DCs) to nonexhausted DCs expressing CD70 and evoking long-lasting type 1 T cell responses.
Iwamoto S, Ishida M, Takahashi K, Takeda K, Miyazaki A.J Leukoc Biol. 2005 Aug;78(2):383-92. Epub 2005 Apr 27.
- 3.
- Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma.
Wischhusen J, Jung G, Radovanovic I, Beier C, Steinbach JP, Rimner A, Huang H, Schulz JB, Ohgaki H, Aguzzi A, Rammensee HG, Weller M.Cancer Res. 2002 May 1;62(9):2592-9.
- 4.
- Direct cellular communications between CD45R0 and CD45RA T cell subsets via CD27/CD70.
Agematsu K, Kobata T, Sugita K, Hirose T, Schlossman SF, Morimoto C.J Immunol. 1995 Apr 15;154(8):3627-35.
- Application Image
- Immunohistochemistry (Frozen sections)
- Immunoprecipitation
- Flow Cytometry
- Entrez GeneID:
- 970
- Gene Name:
- CD70
- Gene Alias:
- CD27L,CD27LG,TNFSF7
- Gene Description:
- CD70 molecule
- Omim ID:
- 602840
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq
- Other Designations:
- CD27 ligand,CD70 antigen,Ki-24 antigen,surface antigen CD70,tumor necrosis factor (ligand) superfamily, member 7,tumor necrosis factor ligand superfamily, member 7
- Gene Pathway